Prevalence of methylenetetrahydrofolate reductase 677 C-T polymorphism among mothers of Down syndrome children

Conclusion: No association has been observed between 677 C-T polymorphism and risk of non-disjunction in case mothers. Detection of polymorphisms in more genes of folate pathway is required to find out the exact cause of non-disjunction.

Source: Indian Journal of Human Genetics - January 4, 2014 Category: Genetics & Stem Cells Authors: Anupam KaurAmandeep Kaur Source Type: research