Neurophysiological changes after cognitive-motor tasks in Parkinson's disease patients with deep brain stimulation.

Neurophysiological changes after cognitive-motor tasks in Parkinson's disease patients with deep brain stimulation. Funct Neurol. 2019 Jul/Sep;34(3):177-187 Authors: Negri M, Gorgora M, Nasser JA, Salles JI, Teixeira S, Arias-Carrión O, Junqueira J, Nicoliche E, Velasques B, Cagy M, Budde H, Basile LF, Orsini M, Friede R, Bastos VH, Ribeiro P Abstract Chronic deep brain stimulation (CDBS) is a surgical treatment that reduces the cardinal signs of Parkinson's disease (PD). Although CDBS has been in use for a long time, very little has been reported on its supposed effects on cognition, particularly in relation to implants in the subthalamic nucleus. The results of the rare studies that do exist are controversial, and in many cases the studies have several design flaws. The present study compared cortical activation during three tasks (action execution, action observation and motor imagery) in PD patients with and without subthalamic implants. The study sample consisted of 36 volunteers, divided into three groups: healthy controls, PD patients with CDBS of the subthalamic nucleus, and PD patients without CDBS. Through a quantitative electroencephalogram assessment, absolute beta power was examined to observe the interaction between group and cognitive motor tasks. The electrodes at sites Fp1, Fp2, F7, F8, F3, Fz and F4, located in the prefrontal and frontal regions, were analyzed and a Group x Task interaction (p < 0.05) was observ...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research