Aspirin resistance: Prevalence and clinical outcome in Egypt

Publication date: Available online 7 January 2015 Source:The Egyptian Journal of Critical Care Medicine Author(s): Ahmed Salah , Mohammed El-Desuky , Amal Rizk , Amr El-Hadidy Introduction The antiplatelet drug aspirin is considered as a cornerstone in medical treatment of patients with CV or cerebrovascular diseases. Despite its use, a significant number of patients had recurrent adverse ischemic events. Inter-individual variability of platelet aggregation in response to aspirin may be an explanation for some of these events. Multiple trials have linked aspirin resistance to these adverse events. Objectives The aim of this study was to estimate the prevalence of aspirin resistance among patients with coronary artery disease (CAD) in Egypt and evaluate its impact on clinical outcome. Methods A total of 50 patients with documented history of CAD were included; they were on aspirin 150mg/day for more than seven days and no other antiplatelet drugs. They were evaluated for aspirin resistance using light transmission aggregometry. Aspirin resistance was defined as a mean aggregation of >20% with 0.5mg/ml arachidonic acid. They were followed up after six months for cardiac death, unstable angina (UA), myocardial infarction (MI), and stroke. Results Prevalence of aspirin resistance was 48% in our study group. Aspirin resistance was significantly higher in patients with family history of CAD (p =0.044), smoking (p =0.011), history of MI (p =0.024), history of pe...
Source: The Egyptian Journal of Critical Care Medicine - Category: Intensive Care Source Type: research