The immune system in the normal endometrium and implications for endometrial cancer development

Many risk factors involved in the etiology of endometrial cancer have been described. Obesity and physical inactivity are two significant risk factors for the development of uterine tumors, along with elevated blood pressure, high energy intake, high serum glucose levels and increased exposure to estrogens (Amant et al., 2005). For some of these risk factors, the effects on and interactions with the immune system have been reported. Hormonal fluctuations during the menstrual cycle have been described to modulate immune functions, as reviewed by Wira et al.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research