Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis [RESEARCH ARTICLE]

In conclusion, culture models, notably PCLS, are insightful to design strategies for liver graft rescue. Defatting can be rapidly achieved by combinations of drugs targeting mitochondrial oxidative metabolism, macro-autophagy and lipogenesis.

Source: DMM Disease Models and Mechanisms - April 28, 2020 Category: Biomedical Science Authors: Aoudjehane, L., Gautheron, J., Le Goff, W., Goumard, C., Gilaizeau, J., Nget, C. S., Savier, E., Atif, M., Lesnik, P., Morichon, R., Chretien, Y., Calmus, Y., Scatton, O., Housset, C., Conti, F. Tags: Metabolic Disorders RESEARCH ARTICLE Source Type: research