Myc-interacting zinc-finger protein 1 positively regulates Wnt signaling by protecting Dishevelled from Dapper1-mediated degradation

In this study, we report that Myc-interacting zinc-finger protein 1 (MIZ1) interacts with Dpr1, and this interaction attenuates the ability of Dpr1 to induce Dvl2 degradation, thus enhancing Wnt signaling. Mechanistically, MIZ1 is translocated from the nucleus to the cytoplasm upon Wnt3a stimulation or over-expression of Dpr1 and Dvl2, disrupting the interaction between Dpr1 and Dvl2. Furthermore, MIZ1 can promote the proliferation of breast cancer MDA-MB-231 and BT-549 cells through Wnt signaling and reverse the anti-proliferative effect of Dpr1 on colorectal cancer Caco-2. Together, our findings establish a novel layer of Wnt signaling regulation via the MIZ1-Dpr1-Dvl axis.

Source: BJ Cell - January 5, 2015 Category: Biochemistry Authors: Y Huang, P Wang, H Chen, Y Ding, Y Chen Tags: BJ Signal Source Type: research