Diethylpyrocarbonate modification reveals HisB5 as an important modulator of insulin amyloid formation

This study not only provides a fast new approach for studying the impact of imidazole ring in amyloid formation, but also reveals the critical modulating role of histidine imidazole ring on the amyloidogenicity of insulin.

Source: Journal of Biochemistry - January 5, 2015 Category: Biochemistry Authors: Yang, X., Li, Y., Huang, L., Zhang, X., Cheng, C., Gong, H., Ma, L., Huang, K. Tags: Regular Papers Source Type: research