Statins and Nitric Oxide Donors Affect Thrombospondin 1-Induced Chemotaxis

Conclusion: Short-term statin pretreatment inhibited TSP-1-induced VSMC chemotaxis, suggesting a pleiotropic effect. High-dose NO reversed statin inhibition of TSP-1-induced chemotaxis, suggesting NO and statin combination therapies warrant further study.

http://ves.sagepub.com/cgi/content/abstract/48/7-8/470?rss=1

Source: Vascular and Endovascular Surgery - January 5, 2015 Category: Surgery Authors: Seymour, K., Stein, J., Han, X., Maier, K. G., Gahtan, V. Tags: Articles Source Type: research