A mathematical model of the colon crypt capturing compositional dynamic interactions between cell types

We report the progressive development, iterative testing and fitting of a developed compartmental model with additional cell types, and which includes feedback mechanisms and cross‐regulatory mechanisms between cell types. The fitting of the model to existing data sets suggests a need to invoke cross‐talk between cell types as a feature of colon crypt cycle models.
Source: International Journal of Experimental Pathology - Category: Pathology Authors: Tags: Original Article Source Type: research