Wild‐type K‐ras has a tumour suppressor effect on carcinogen‐induced murine colorectal adenoma formation

In conclusion, the data collectively show that a 50% reduction in K‐ras gene dosage and RNA expression promoted experimental colorectal tumourigenesis, consistent with wild‐type K‐ras having a tumour suppressor effect on carcinogen‐induced murine colorectal adenoma formation.

Source: International Journal of Experimental Pathology - December 20, 2013 Category: Pathology Authors: Feijun Luo, George Poulogiannis, Hongtao Ye, Rifat Hamoudi, Gehong Dong, Wenyan Zhang, Ashraf E. K. Ibrahim, Mark J. Arends Tags: Original Article Source Type: research