Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia

Conclusions: Collectively, our findings demonstrate for the first time the important role of Cdk5 in orofacial mechanical nociception. Modulation of Cdk5 activity in primary sensory neurons makes it an attractive potential target for the development of novel analgesics that could be used to treat multiple orofacial pain conditions.
Source: Molecular Pain - Category: Molecular Biology Authors: Source Type: research