3-Aminofurostane Alkaloids from Solanum paniculatum (“Jurubeba Verdadeira”) Roots

In this study, three principal alkaloids were isolated in mixture, and their structures were established by different spectroscopic methods, including 1D, 2D nuclear magnetic resonance (NMR) experiments, and the high-resolution electrospray ionization (HR-ESI)-MS analysis. The isolated alkaloids were used to explore fragmentation pathways. Compound identification was based on the exact mass and fragmentation behaviors. Two compounds were identified as new natural compounds as: (25R)-3 β -amino-furost-5-en-22 α ,26-diol O(26)- β -D-glucopyranoside (fatimagraine) and (25R)-3 β -amino-furost-22-en,26-ol O(26)- β -D-glucopyranoside (bhattacharyyaine). The unambiguous assignments of 1H and 13C NMR data and chemical correction of the structure alkaloid jurubine are reported for the first time.
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research