Reduction of Early Reperfusion Injury With the Mitochondria-Targeting Peptide Bendavia

In conclusion, Bendavia is a promising candidate to reduce cardiac injury when present at the onset of reperfusion but not after reperfusion has already commenced. Given that both infarction and no-reflow are related to increased cellular ROS, Bendavia’s protective mechanism of action likely involves reduced ROS generation (as opposed to augmented scavenging) by endothelial and myocyte mitochondria.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 17, 2013 Category: Cardiology Authors: Brown, D. A., Hale, S. L., Baines, C. P., Rio, C. L. d., Hamlin, R. L., Yueyama, Y., Kijtawornrat, A., Yeh, S. T., Frasier, C. R., Stewart, L. M., Moukdar, F., Shaikh, S. R., Fisher-Wellman, K. H., Neufer, P. D., Kloner, R. A. Tags: Experimental Studies Source Type: research