Assessment of a Nonsteroidal Aromatase Inhibitor, Letrozole, in Juvenile Rats

CONCLUSIONSThe observed effects in juvenile rats were considered predictable and primarily related to the mechanism of action of letrozole upon estrogen synthesis.

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 9, 2013 Category: Perinatology & Neonatology Authors: Louise Pouliot, Marilynn Schneider, Marc DeCristofaro, Rana Samadfam, Susan Y. Smith, David A. Beckman Tags: Original Article Source Type: research