Intrathecal leptin inhibits expression of the P2X2/3 receptors and alleviates neuropathic pain induced by chronic constriction sciatic nerve injury

Conclusions: Our findings suggest that exogenous leptin can alleviate the chronic neuropathic pain caused by CCI. The leptin effect may be mediated by attenuated expression of IL-6, TNFalpha, and the P2X2 and P2X3 receptors in the DRG of CCI rats.

http://www.molecularpain.com/content/9/1/65

Source: Molecular Pain - December 10, 2013 Category: Molecular Biology Authors: Xin LiLumei KangGuilin LiHuihong ZengLei ZhangXiang LingHui DongShangdong LiangHongping Chen Source Type: research