Mutated CaV2.1 channels dysregulate CASK/P2X3 signaling in mouse trigeminal sensory neurons of R192Q Cacna1a knock-in mice

Conclusions:
We propose that, in trigeminal sensory neurons, the CASK/P2X3 complex has a dynamic nature depending on intracellular calcium and related signaling, that are enhanced in a transgenic mouse model of genetic hemiplegic migraine.

Source: Molecular Pain - December 2, 2013 Category: Molecular Biology Authors: Aswini GnanasekaranTanja BeleSwathi HullugundiManuela SimonettiMichael FerrariArn van den MaagdenbergAndrea NistriElsa Fabbretti Source Type: research