Mechanical sensitization of cutaneous sensory fibers in the spared nerve injury mouse model

Conclusions: To our knowledge, this is the first study evaluating the contribution of primary afferent fibers in the SNI model. These data suggest that enhanced suprathreshold firing in AM and C fibers may play a role in the marked, persistent mechanical hypersensitivity observed in this model. These results may provide insight into mechanisms underlying neuropathic pain in humans.
Source: Molecular Pain - Category: Molecular Biology Authors: Source Type: research