Mechanical sensitization of cutaneous sensory fibers in the spared nerve injury mouse model
Conclusions:
To our knowledge, this is the first study evaluating the contribution of primary afferent fibers in the SNI model. These data suggest that enhanced suprathreshold firing in AM and C fibers may play a role in the marked, persistent mechanical hypersensitivity observed in this model. These results may provide insight into mechanisms underlying neuropathic pain in humans.
Source: Molecular Pain - Category: Molecular Biology Authors: Amanda SmithCrystal O¿HaraCheryl Stucky Source Type: research