Guluronate oligosaccharides as enhancers of nanoparticle drug delivery in the oral cavity

Publication date: Available online 31 December 2014 Source:Bioactive Carbohydrates and Dietary Fibre Author(s): Catherine Taylor Nordgård , Astrid Bjørkøy , Kurt I. Draget Guluronate oligomers have been shown to modify the gastrointestinal mucus barrier and improve nanoparticle penetration. Here we investigate the effect of guluronate oligomers on nanoparticle mobility in saliva, a central extracellular barrier in the oral cavity. Guluronate oligomers reduced nanoparticle aggregation in saliva and improved nanoparticle mobility over and above that which would be expected to result from the decrease in size. As such guluronate oligomers may be of interest for nanomedicine delivery in the oral cavity. Graphical abstract
Source: Bioactive Carbohydrates and Dietary Fibre - Category: Food Science Source Type: research