Intravascular Radiocontrast Iodixanol Increases Permeability of Proximal Tubule Epithelium: A Possible Mechanism of Contrast-Induced Nephropathy

Conclusions:
Our in vitro data do not support the hypothesis that direct kidney cell death from Iodixanol is a major mechanism of contrast-induced nephropathy (CIN). However, increased permeability of proximal tubule epithelium caused by Iodixanol may play an important role in CIN.

Source: Vascular and Endovascular Surgery - November 10, 2013 Category: Surgery Authors: Yao, L., Kolluru, G. K., Kevil, C. G., Zhang, W. W. Tags: Basic Research Articles Source Type: research