Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Conclusions:
Based on these findings, we conclude that loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Harish ChanderColin BrienPeter TruesdellKathleen WattJalna MeensColleen SchickDoris GermainAndrew Craig Source Type: research