Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves

ConclusionsA low AMF bioavailability was due to extensive glucuronidation, which was mediated by UGT1A1 and UGT1A3. Glucuronidated AMF metabolites had the same antioxidant but had a lower anticancer activity than that of AMF.

Source: Journal of Pharmacy and Pharmacology - March 8, 2020 Category: Drugs & Pharmacology Authors: Lili Gan, Jiating Ma, Guoquan You, Jinxia Mai, Zhaoyu Wang, Ruopeng Yang, Cong Xie, Jingrao Fei, Lan Tang, Jie Zhao, Zheng Cai, Ling Ye Tags: Research Paper Source Type: research