HPV and non-HPV related subtypes of penile squamous cell carcinoma (SCC): Morphological features and differential diagnosis according to the new WHO classification (2015).

The majority of penile carcinomas are squamous cell carcinomas originating in the squamous mucosa covering glans, coronal sulcus or inner surface of the foreskin, the 3 latter sites comprising the penile anatomical compartments. There is a variegated spectrum of subtypes of penile squamous cell carcinomas, according to recent classification schemes. Currently, because of etiological and prognostic considerations, 2 morphologically and molecularly distinctive groups of subtypes of penile SCCs based on the presence of HPV were delineated.
Source: Seminars in Diagnostic Pathology - Category: Pathology Authors: Source Type: research