Gq rather than G11 preferentially mediates nociceptor sensitization

Conclusions: Our results demonstrate that the Gq/11 signaling branch plays a primary role in nociceptor sensitization upon stimulation with classical GPCR ligands, contributing primarily towards the development of mechanically allodynia. Moreover, the deletion of the individual G-proteins led to the finding that the Gq-protein dominates the signalling machinery of the Gq/11 family of G-proteins in nociceptive neurons.
Source: Molecular Pain - Category: Molecular Biology Authors: Source Type: research