The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy
Conclusions:
Oxaliplatin induced painful peripheral neuropathy in mice, an effect that was prevented by rutin and quercetin. The mechanism of action of oxaliplatin appears to be, at least, partially oxidative stress-induced damage in dorsal horn neurons, with the involvement of lipid peroxidation and protein nitrosylation.
Source: Molecular Pain - Category: Molecular Biology Authors: Maria AzevedoAnamaria PereiraRicardo NogueiraFlávio RolimGerly BritoDeysi WongRoberto Lima-JúniorRonaldo de Albuquerque RibeiroMariana Vale Source Type: research
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