Multivalent interactions of the SUMO-interaction motifs in the RING-finger protein 4 (RNF4) determine the specificity for chains of the small ubiquitin-related modifier (SUMO)

We describe that the sequence and spacing of the SUMO-interaction motifs (SIMs) in RNF4 regulate the avidity-driven recognition of substrate proteins carrying SUMO chains of variable length.

Source: BJ Signal - October 23, 2013 Category: Biochemistry Authors: K Keusekotten, V N. Bade, K Meyer-Teschendorf, A Miriam Sriramachandran, K Fischer-Schrader, A Krause, C Horst, G Schwarz, K Hofmann, R Jürgen Dohmen, G J.K. Praefcke Tags: BJ Signal Source Type: research