Dietary cellulose nanofiber modulates obesity and gut microbiota in high-fat-fed mice

Publication date: Available online 20 February 2020Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Takao Nagano, Hiromi YanoAbstractCellulose nanofiber (CN) has a unique feature of dispersing in water and producing a dispersion of high viscosity, similar to highly viscous soluble dietary fibers (DFs). The beneficial effects of soluble DFs on glycemic control are associated with viscosity, thus making CN a potential option to attenuate obesity and related diseases. Here, we studied the effects of CN intake on obesity and gut microbiota in high-fat diet (HFD)-fed mice. The CN-treated mice were provided 0.1% or 0.2% CN dispersions via drinking water for seven weeks. HFD-fed mice weighed more than mice fed a normal-fat diet (NFD). The weight gain in HFD-fed mice was suppressed in 0.2% CN-treated group, but not in 0.1% CN-treated group, when compared with CN-untreated group. Also, the accumulation of epididymal and subcutaneous fat in HFD-fed mice was lower in 0.2% CN treated group than in the CN-untreated group. Moreover, the fecal gut microbiota was analyzed by sequencing bacterial 16S ribosomal RNA genes. Oral administration of 0.2% CN, but not 0.1% CN, increased bacterial diversity and induced changes in the gut microbiota composition of HFD-fed mice. The principal component analysis (PCA) at the phylum level showed a shift in the microbiota composition resulting from feeding HFD. This shift in the PC1 axis was reversed by 0.2% CN intake. In addition, the relative ...
Source: Bioactive Carbohydrates and Dietary Fibre - Category: Food Science Source Type: research