Mitochondrial Complex I Inhibition by Metformin: Drug–Exercise Interactions

Publication date: Available online 20 February 2020Source: Trends in Endocrinology & MetabolismAuthor(s): S. Martín-Rodríguez, P. de Pablos-Velasco, J.A.L. CalbetMetformin has antidiabetic, anticancer, and prolongevity effects, but seems to interfere with aerobic training mitochondrial adaptations. The primary mechanism of action has been suggested to be the inhibition of mitochondrial complex I. Recent papers (Wang et al. and Cameron et al.), however, provide evidence to deny the hypothesis of a direct action of metformin on complex I.
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research