Sensitivity of inhalation anesthetics isoflurane and sevoflurane for the drug-induced QT-interval prolongation in guinea pigs

Publication date: Available online 21 February 2020Source: Journal of Pharmacological SciencesAuthor(s): Yoshinobu Nagasawa, Kaori Sakai, Rui Kurimoto, Satoshi Kawakami, Megumi Aimoto, Akira TakaharaAbstractWe investigated effects of isoflurane and sevoflurane on sparfloxacin-induced QT-interval prolongation in guinea pigs under the monitoring of electrocardiogram and monophasic action potential (MAP), which was compared with that of halothane or non-inhaled anesthetics ketamine/xylazine. Intravenous administration of sparfloxacin at 3 and 10 mg/kg prolonged the QT interval and MAP duration together with bradycardic action under 4 different anesthetic conditions. The order of extent of prolongation of corrected QT interval after the administration of sparfloxacin was isoflurane ≈ sevoflurane ≈ halothane>> ketamine/xylazine, whereas that of the MAP90 at pacing cycle lengths of 300 ms was halothane ≥ isoflurane ≈ sevoflurane>> ketamine/xylazine. These results suggest that isoflurane and sevoflurane as well as halothane could sensitize the heart to sparfloxacin-induced QT interval prolongation in guinea pigs.
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research