The Role of MicroRNA-155 in Chlamydia muridarum Infected Lungs

Publication date: Available online 19 February 2020Source: Microbes and InfectionAuthor(s): Jonathon Keck, James P. Chambers, Aravind Kancharla, Dona Haj Bashir, Laura Henley, Katherine Schenkel, Kevin Castillo, M. Neal Guentzel, Rishein Gupta, Bernard P. ArulanandamAbstractOur laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research