Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination

Publication date: Available online 18 February 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Anastasiia S. Garanina, Victor A. Naumenko, Aleksey A. Nikitin, Eirini Myrovali, Anna Y. Petukhova, Svetlana V. Klimyuk, Yulia A. Nalench, Artem R. Ilyasov, Stepan S. Vodopyanov, Alexander S. Erofeev, Peter V. Gorelkin, Makis Angelakeris, Alexander G. Savchenko, Ulf Wiedwald, Alexander G. Majouga Dr, Maxim A. AbakumovAbstractMagnetic hyperthermia (MHT) is a promising approach for cancer therapy. However, a systematic MHT characterization as function of temperature on the therapeutic efficiency is barely analyzed. Here, we first perform comparative temperature-dependent analysis of the cobalt ferrite nanoparticles-mediated MHT effectiveness in two murine tumors models – breast (4 T1) and colon (CT26) cancer in vitro and in vivo. The overall MHT killing capacity in vitro increased with the temperature and CT26 cells were more sensitive than 4 T1 when heated to 43 °C. Well in line with the in vitro data, such heating cured non-metastatic CT26 tumors in vivo, while only inhibiting metastatic 4 T1 tumor growth without improving the overall survival. High-temperature MHT (>47 °C) resulted in complete 4 T1 primary tumor clearance, 25–40% long-term survival rates, and, importantly, more effective prevention of metastasis comparing to surgical extraction. Thus, the specific MHT temperature must be defined for each tumor individually to ensure a successful antit...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research