Stress and cortisol in Parkinson's disease

Publication date: Available online 19 February 2020Source: International Review of NeurobiologyAuthor(s): Daniel J. van Wamelen, Yi-Min Wan, K. Ray Chaudhuri, Peter JennerAbstractStress is ubiquitous with many factors contributing to its effects, including psychological responses and associated biological factors, including cortisol related physiological responses, and inflammation. Also in Parkinson's disease there is growing evidence for the role of stress in some key symptoms, even stretching to the prodromal stage. Here we discuss the possible contributions of the range and nature of stress in PD and we aim to summarize the current knowledge about the role of stress-related responses on motor and non-motor symptoms, the underlying pathophysiology, and the potential implications for treatment.
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research