TSH/IGF1 receptor crosstalk: Mechanism and clinical implications

Publication date: Available online 13 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Christine C. Krieger, Susanne Neumann, Marvin C. GershengornAbstractIncreasing evidence of interdependence between G protein-coupled receptors and receptor tyrosine kinase signaling pathways has prompted reevaluation of crosstalk between these receptors in disease and therapy. Investigations into thyroid-stimulating hormone (TSH) and insulin-like growth factor 1 (IGF1) receptor crosstalk, and its application to the clinic have in particular shown recent progress. In this review, we summarize current insights into the mechanism of TSH/IGF1 receptor crosstalk. We discuss evidence that crosstalk is one of the underlying causes of TSHR-based disease and the feasibility of using combinations of TSH receptor and IGF1 receptor antagonists to increase the therapeutic index for the treatment of Graves' hyperthyroidism and Graves' ophthalmopathy.
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research