Evidence Mapping of Interactions on Concomitant Use of Traditional Chinese Medicine and Platinum-based Chemotherapy: A Scoping Review Protocol

This study aims to update the current knowledge on herbal-drug interactions of the commonly used platinum-based chemotherapy (PtC) in cancer patients.MethodsSystemic searches will perform on online databases (English and Chinese) to identify papers from inception until December 2019 for inclusion into the review. The search strategy will be following PRISMA Scoping Reviews Checklist as a quality assurance step. All records retrieved will be screened by 2 independent reviewers. The preclinical studies and clinical studies that involves in assessing the concurrent use of CHM and PtC will be considered. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses will be used as scoping review framework. Two reviewers will perform the search process independently. One author will extract data, and another will cross-check as per delineated research questions and goals. Any disagreements will be solved by a third reviewer.DiscussionThis scoping review is to explore the compatibility or combination rule of CHM-PtC and understand HDI in CHM-PtC cotreatment as identification active properties in CHM, HDI interactions and understanding pharmacokinetics and pharmacodynamic of the CHM alone or cotreatment are essential for patients’ safety profile. It will provide a new insight for future practice in cancer treatment.Study registrationThis protocol has been registered in the Research Register (https://www.researchregistry.com/) with unique identify number is reviewregistry7...
Source: Integrative Medicine Research - Category: Complementary Medicine Source Type: research