Spanish allele and haplotype database for 32 X-chromosome Insertion-Deletion polymorphisms

Publication date: Available online 13 February 2020Source: Forensic Science International: GeneticsAuthor(s): Cláudia Gomes, José David Quintero-Brito, Jesús Martínez-Gómez, Rui Pereira, Carlos Baeza-Richer, Mercedes Aler Gay, Laura Díez-Juárez, Sara Palomo-Díez, Ana María López-Parra, Elena Labajo, Victor José Esteban-Ramos, Bernardo Perea-Pérez, Eduardo Arroyo-PardoAbstractX-chromosome markers have been proved to be decisive both complementing and solving kinship analysis, particularly when autosomal markers are not able to produce adequate likelihood ratios between different hypothesis. On the other hand, Pereira et al., (2012) have demonstrated that 32 Insertion/Deletion (InDel) markers located on the X-Chromosome have a very important power of discrimination in human populations, being a novel tool in the forensic and population fields. So, the aim of the present work was testing the forensic and population genetic efficiency of the 32 X-InDel polymorphisms in the Spanish population, and subsequently build an allele/haplotype frequencies database.To accomplish this objective, a total of 555 samples comprising male individuals from 13 Spanish regions were analysed for the above mentioned 32 X-InDels in two independent laboratories. A pairwise FST analysis was performed in order to understand if the studied Spanish sub-populations present significant differences among them, detecting possible population substructure. Also, linkage disequilibrium analyses were c...
Source: Forensic Science International: Genetics - Category: Forensic Medicine Source Type: research