Research methods and baseline findings of the improving the safety of opioid therapy (ISOT) cluster-randomized trial

There are adverse effects associated with long-term opioid therapy (LTOT) for chronic pain and clinicians infrequently adhere to opioid treatment guideline recommendations for reducing risk and mitigating opioid-related harms. The primary goal of the Improving the Safety of Opioid Therapy (ISOT) intervention is to reduce harms related to prescription opioids. Secondary aims focus on enhancing the clinician-patient relationship and not having a negative impact on pain-related outcomes (to be examined through a non-inferiority analysis).

Source: Contemporary Clinical Trials - February 12, 2020 Category: Radiology Authors: Benjamin J. Morasco, Melissa H. Adams, Patricia E. Maloy, Elizabeth R. Hooker, Megan O. Iacocca, Erin E. Krebs, Thomas P. Carr, Travis I. Lovejoy, Somnath Saha, Steven K. Dobscha Source Type: research