Quetiapine dose optimisation during gestation: a pharmacokinetic modelling study

ConclusionsQuetiapine doses in pregnancy should be increased to 500 –700 mg twice daily to counteract a concomitant increase in metabolic clearance, increase in volume of distribution and decrease in plasma protein binding.

Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Raj K. S. Badhan, Hannah Macfarlane Tags: Research Paper Source Type: research