Cell ‐based, animal and H1 receptor binding studies relative to the sedative effects of ketotifen and norketotifen atropisomers

ConclusionThe lower sedative effect of SN in rodents is probably due to a combination of a lower uptake of N than K into the brain and less affinity of SN for CNS H1 receptors.

Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Feifei Feng, J. Paul Fawcett, Hu Zhang, Ian G. Tucker Tags: Research Paper Source Type: research