Compound selected by in silico methodologies bloking the C. albicans adhesion and biofilm process on abiotic surface

The objective of the present study was to evaluate whether the small molecule F2768-0318, which was selected by in silico methodologies against NT-Als3 domain, will be able to block the C. albicans adhesion on abiotic and biotic surfaces. F2768-0318 was assessed in tests of biofilm formation and adhesion on abiotic surfaces (polystyrene plates) and adherence on biotic surfaces, including human endocervical (HeLa) cells, human umbilical vein endothelial cells (HUVEC), and fresh buccal epithelial cells (BEC). Our results showed a good performance of F2768-0318 in reducing the adhesion and biofilm formation of C. albicans on abiotic surfaces, indicating the possibility of treating hospital materials and preventing biofilm formation on these types of equipment. Further studies are still needed, including optimization of the molecule to allow this molecule to be effective on other types of surfaces, such as human cells.

Source: Journal of Medical Mycology - February 13, 2020 Category: Biology Source Type: research