The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Publication date: Available online 10 February 2020Source: Antiviral ResearchAuthor(s): B. Coutard, C. Valle, X. de Lamballerie, B. Canard, N.G. Seidah, E. DecrolyAbstractIn 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
Source: Antiviral Therapy - Category: Virology Source Type: research