Construction and analysis of single nucleotide polymorphism??single nucleotide polymorphism interaction networks

In this study, the authors are interested in single nucleotide polymorphism (SNP) level and construct SNP??SNP interaction network to understand genetic characters and pathogenetic mechanisms of complex diseases. The authors employ existing methods to mine, model and evaluate a SNP sub-network from SNP??SNP interactions. In the study, the authors employ the two SNP datasets: Parkinson disease and coronary artery disease to demonstrate the procedure of construction and analysis of SNP??SNP interaction networks. Experimental results are reported to demonstrate the procedure of construction and analysis of such SNP??SNP interaction networks can recover some existing biological results and related disease genes.
Source: IET Systems Biology - Category: Biology Source Type: research