The effect of physical preparedness levels on serum levels of CC16, SP-D and lung function in endurance runners

Publication date: Available online 5 February 2020Source: Science & SportsAuthor(s): H. Pourmanaf, A. Hamzehzadeh, L. NikniazSummaryObjectivesEndurance runners are exposed to respiratory damages due to extreme endurance exercises. Increasing CC16 and SP-D in the bloodstream is a sign of respiratory tract damage. The purpose of this pilot study was to investigate the effect of physical preparedness levels on serum CC16 and SP-D levels and lung function.Equipment and methodsTen healthy male elite runners and ten healthy male recreational runners were recruited based on the inclusion and exclusion criteria. Lung permeability [Surfactant protein D (SP-D), the Clara cell secretory protein (CC16) in serum and CC16/SP-D ratio] and lung function (FEV1, FVC and FEV1/FVC ratio) were measured before and after endurance session of running with an intensity of 80% to 85% maximum heart rate for 30 minutes. Comparisons were performed by RM-ANCOVA.ResultsSerum CC-16 and SP-D levels, and CC16/SP-D ratio increased significantly with time (P = < 0.001). Also, the interaction of group × time and between group changes was not significant for serum CC-16 and SP-D levels, and CC16/SP-D ratio (P > 0.05). However, FEV1, FVC, FEV1/FVC ratio decreased significantly with time (P ≤ 0.05). Also, the interaction of group × time and between group changes was not significant for FEV1, FVC, FEV1/FVC ratio (P > 0.05). Based on the re...
Source: Science and Sports - Category: Sports Medicine Source Type: research