DELs Inside Cells

Publication date: Available online 4 February 2020Source: Trends in Pharmacological SciencesAuthor(s): Animesh Roy, Thomas KodadekDNA-encoded libraries (DELs) comprise large numbers of small molecules, each of which is conjugated to an encoding DNA. Krusemark and colleagues recently described a method to introduce DELs into living cells and recover conjugates that bind to an intracellular target. This proof-of-principle study suggests that it may be feasible to screen DELs against protein targets in their native environment.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research