A parametric multiple test procedure to adaptive group-sequential trials allowing for mid-term modifications

Adaptive group-sequential trials incorporating mid-term design modifications, such as selection of hypotheses or treatment groups, or sample size reestimation during the interim analysis, provide efficient tools to utilize the data from enrolled patients. A graphical multiple test procedure using weighted Bonferroni test has been proposed in adaptive group-sequential designs based on a marginal p-value combination approach.Multiple test procedures using weighted Bonferroni test may result in potential power loss when the test statistics are positively correlated.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Source Type: research