Potential use of 1,3,6-trihydroxy-4,5,7-trichloroxanthone and doxorubicin combination on B-cell lymphoma and its mechanism of actions through molecular docking study

ConclusionsThe xanthone-doxorubicin combination showed promising in vitro activity against lymphoma cells. The results also indicate that the TTX and doxorubicin combination's effect was due to the interaction between TTX with Raf-1 and JNK receptors, two determinants of doxorubicin resistance progression.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research