Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction

ConclusionWe present (d-Arg35)-sea lamprey PYY (1–36) as the first-in-class N- and C-terminally stable PYY (1–36) peptide analogue.General significanceEnzymatically stable, long-acting PYY (1–36) peptides highlight the therapeutic benefits of sustained activation of NPYR1's in diabetes.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research