Proteomic analysis of differentially expressed proteins in Vitamin C-treated AGS cells

Background: Vitamin C (ascorbic acid) is an essential nutrient of most living tissues that readily acts as a strong reducing agent, which is abundant in fruits and vegetables. Although, it inhibits cell growth in many human cancer cells in vitro, treatment in cancer is still controversial. Hence, the purpose of this study was to investigate the molecular mechanism of the inhibitory effect of vitamin C on AGS cell growth, and protein profiles in AGS cells after exposure to vitamin C treatment, by using proteomic tools. Results: Vitamin C showed a cytotoxic effect on AGS cells (IC50 300mug/mL) and, 20 differentially expressed proteins (spot intensities which show >=2 fold change and statistically significant, p
Source: BMC Biochemistry - Category: Biochemistry Authors: Source Type: research