Adherence-adjustment in placebo-controlled randomized trials: An application to the candesartan in heart failure randomized trial

Adherence adjustment in the CHARM trial is feasible when appropriate assumptions about missing data and confounding are made. These assumptions cannot be verified but can be supported through the use of placebo-arm adherence assessment.

Source: Contemporary Clinical Trials - January 22, 2020 Category: Radiology Authors: Eleanor J. Murray, Brian L. Claggett, Bradi Granger, Scott D. Solomon, Miguel A. Hern án Source Type: research