Molecular mechanisms in Cognitive Frailty: potential therapeutic targets for oxygen-ozone treatment

Publication date: Available online 23 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Catia Scassellati, Miriam Ciani, Antonio Carlo Galoforo, Roberta Zanardini, Cristian Bonvicini, Cristina GeroldiAbstractIn the last decade, cognitive frailty has gained great attention from the scientific community. It is characterized by high inflammation and oxidant state, endocrine and metabolic alterations, mitochondria dysfunctions and slowdown in regenerative processes and immune system, with a complex and multifactorial aetiology. Although several treatments are available, challenges regarding the efficacy and the costs persist. Here, we proposed an alternative non-pharmacological, non-side-effect, low cost therapy based on anti-inflammation, antioxidant, regenerative and anti-pathogens properties of ozone (O3), through the activation of several molecular mechanisms (Nrf2-ARE, NF-κB, NFAT, AP-1, HIFα). We highlighted how these specific processes could be implicated in cognitive frailty to identify putative therapeutic targets for its treatment.The O2-O3 therapy has never been tested for cognitive frailty. This work provides thus wide scientific background to build a consistent rationale for testing for the first time this therapy, that could modulate the immune, inflammatory, oxidant, metabolic, endocrine, microbiota and regenerative processes impaired in cognitive frailty.Although insights are needed, the O2-O3 therapy could represent a faster, easier, inexpensiv...

Source: Mechanisms of Ageing and Development - January 23, 2020 Category: Geriatrics Source Type: research