Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens

Publication date: Available online 18 January 2020Source: Trends in Pharmacological SciencesAuthor(s): Sarah Zych, Christopher P. FordTo investigate how opioid exposure alters dopamine (DA) responses in medium spiny neurons (MSNs), Muntean et al. used a novel cAMP sensor to track cAMP dynamics and report a coordinated effort of adaptations in D1- and D2-MSNs to integrate DA inputs and shift signaling strengths in various states of opioid dependence.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research