Human skin microbiota in various phases of atopic dermatitis

We present the results of our study on the microbiota of apparently healthy skin in children with atopic eczema (AE) exacerbation and skin microbiota in remission. The study revealed that the skin microbiota in children with AE signi ficantly differs from that of healthy controls. The differences include not the quantitative but also qualitative skin microbiota composition both on AE lesions and apparently healthy skin, where the bacterial number exceeds that on the skin of the control group children by 2-4 times. We also observ ed qualitative bacterial imbalance and appearance and prevalence of microorganisms not typical for healthy skin, where saprophyticStaphylococcus is the basis of microbiota, whileStaphylococcus aureus was the basis in patients with AE. The skin microbiota in children with AE in remission also differed significantly from the skin microbial flora in healthy children. The skin in remission was highly contaminated with microorganisms, in particular pathogens, which indicates sustained alterations of skin microbiota as an unfavorable prognostic factor that can provoke disease relapse. 

Source: Acta Dermatovenerologica Croatica - January 17, 2020 Category: Dermatology Source Type: research